Apolipoprotein E4
MESHD053327
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Synonyms
- Apo E epsilon 4
- Apo E-4
- Apo E 4
- Apo E4
- ApoE4
- Apolipoprotein E-4
- Apolipoprotein E 4
Source last updated 2026-05-24T15:24:51.397Z