Cytochrome-B(5) Reductase
MESHD042966
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Synonyms
- NADH Cytochrome B5 Reductase
- NADH-Cytochrome B5 Reductase
- B5 Reductase, NADH-Cytochrome
- Methemoglobin Reductase
- Reductase, Methemoglobin
- NADH Methemoglobin Reductase
- Methemoglobin Reductase, NADH
- Reductase, NADH Methemoglobin
- NADH-Ferrihemoglobin Reductase
- NADH Ferrihemoglobin Reductase
- Reductase, NADH-Ferrihemoglobin
Source last updated 2026-05-24T15:25:13.889Z