ATP Binding Cassette Transporter, Subfamily B
MESHD018435
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Synonyms
- ATP Binding Cassette Transporter, Sub-Family B
- ATP Binding Cassette Transporter, Sub Family B
- ATP-Binding Cassette, Sub-Family B Proteins
- ATP Binding Cassette, Sub Family B Proteins
- Multidrug Resistance Proteins
- P-Glycoproteins
- P Glycoproteins
Source last updated 2026-05-24T15:25:50.894Z