Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Synonyms
- Cytochrome P 450 Enzyme System
- P-450 Enzyme
- Enzyme, P-450
- P 450 Enzyme
- P450 Enzyme
- Enzyme, P450
- Cytochrome P-450
- Cytochrome P 450
- Cytochrome P450
- P-450 Enzymes
- Enzymes, P-450
- P 450 Enzymes
- P450 Enzymes
- Enzymes, P450
- Cytochrome P-450 Enzymes
- Cytochrome P 450 Enzymes
- Enzymes, Cytochrome P-450
- P-450 Enzymes, Cytochrome
- Cytochrome P450 Superfamily
- Superfamily, Cytochrome P450
- Cytochrome P-450 Superfamily
- Cytochrome P 450 Superfamily
- Superfamily, Cytochrome P-450
- Cytochrome p450 Families
- Cytochrome P-450 Families
- Cytochrome P 450 Families
- CYP450 Superfamily
- Superfamily, CYP450
- Cytochrome P-450 Enzyme
- Cytochrome P 450 Enzyme
- Enzyme, Cytochrome P-450
- P-450 Enzyme, Cytochrome
- CYP450 Family
- Cytochrome P-450 Oxygenase
- Cytochrome P 450 Oxygenase
- Cytochrome P-450 Monooxygenase
- Cytochrome P 450 Monooxygenase
- Monooxygenase, Cytochrome P-450
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Monooxygenase, Cytochrome P-450-Dependent
Source last updated 2026-05-24T15:27:50.522Z