Acth-Independent Macronodular Adrenal Hyperplasia

An endogenous form of adrenal Cushing syndrome characterized by multiple bilateral adrenocortical nodules that cause a striking enlargement of the ADRENAL GLANDS. Although some familial cases have been reported, the vast majority of AIMAH cases are sporadic. Patients typically present in the fifth and sixth decades of life, approximately 10 years later than most patients with other causes of Cushing syndrome. Somatic mutations in the GNAS gene have been identified. OMIM: 219080

Source last updated 2026-05-24T15:30:00.741Z