Medical dictionary
Medical terminology normalized via MeSH, ICD-11, SNOMED CT.
62,341 terms indexed
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
A plant genus of the family ASTERACEAE that contains phenyl propanoids.
A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.
A family of fungi, order POLYPORALES, found on decaying wood.
The apparent deflection (Coriolis acceleration) of a body in motion with respect to the earth, as seen by an observer on the earth, attributed to a fictitious force (Coriolis force) but actually caused by the rotation of the earth. In a medical context it refers to the physiological effects (nausea, vertigo, dizziness, etc.) felt by a person moving radially in a rotating system, as a rotating space station. (From Random House Unabridged Dictionary, 2d ed and McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Oil from ZEA MAYS or corn plant.
A plant family of the order Cornales, subclass Rosidae, class Magnoliopsida that is a loose grouping of woody ornamentals: 11 of its 14 genera have been placed in single families by some authorities. Some botanists combine members of NYSSACEAE into this family.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Diseases of the cornea.
Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect.
A hereditary band-shaped opacity of the cornea , affecting the pupil and palpebral fissure (space between eyelids). The central region is more dense and contains grey, grainy elements. OMIM: 217500
mutations in SLC4A11
mutaitons in ZEB1
An autosomal dominant form of hereditary corneal dystrophy due to a defect in cornea-specific KERATIN formation. Mutations in the genes that encode KERATIN-3 and KERATIN-12 have been linked to this disorder.
mutation in TGFBI
Hereditary corneal dystrophy characterized by metaplasia and overgrowth of corneal endothelial cells. Symptoms can vary significantly, even within the same family. It is caused by a mutation in the OVOL2 gene. OMIM: 122000
An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
Loss of CORNEAL ENDOTHELIUM usually following intraocular surgery (e.g., cataract surgery) or due to FUCHS' ENDOTHELIAL DYSTROPHY; ANGLE-CLOSURE GLAUCOMA; IRITIS; or aging.
Damage or trauma inflicted to the CORNEA by external means.
Fibroblasts which occur in the CORNEAL STROMA.
New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.
Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
Measurement of the thickness of the CORNEA.
A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.
The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
Surgical techniques on the CORNEA employing LASERS, especially for reshaping the CORNEA to correct REFRACTIVE ERRORS.
The measurement of curvature and shape of the anterior surface of the cornea using techniques such as keratometry, keratoscopy, photokeratoscopy, profile photography, computer-assisted image processing and videokeratography. This measurement is often applied in the fitting of contact lenses and in diagnosing corneal diseases or corneal changes including keratoconus, which occur after keratotomy and keratoplasty.
Partial or total replacement of the CORNEA from one human or animal to another.
Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
Asymmetries in the topography and refractive index of the corneal surface that affect visual acuity.
Self-administered health questionnaire developed to obtain details of the medical history as an adjunct to the medical interview. It consists of 195 questions divided into eighteen sections; the first twelve deal with somatic complaints and the last six with mood and feeling patterns. The Index is used also as a personality inventory or in epidemiologic studies.
A family of low molcular-weight proteins that contain PROLINE-RICH PROTEIN DOMAINS. Members of this family play a role in the formation of an insoluble cornified envelope beneath the plasma membrane of stratified squamous epithelial cells.