Medical dictionary
Medical terminology normalized via MeSH, ICD-11, SNOMED CT.
62,341 terms indexed
Gene ID: 835165
structure in first source
RefSeq NM_027435
RefSeq NM_001039211
RefSeq NM_001142744
RefSeq NM_033064
RefSeq NM_001131028
ATG - AUTOPHAGY-RELATED; RefSeq NM_114819
ATG - AUTOPHAGY-RELATED; RefSeq NM_112763
ATG - AUTOPHAGY-RELATED; RefSeq NM_116061
RefSeq NM_018036
RefSeq NM_024085
a pepducin
stimulates efflux of cholesterol from cells
RefSeq NM_103813
RefSeq NM_000051
A superfamily of integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE, characterized by accumulation of cholesteryl ester in various tissues.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typhimurium. ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5'-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17.
Multisubunit enzyme complexes that synthesize ADENOSINE TRIPHOSPHATE from energy sources such as ions traveling through channels.
GenBank D13123
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.
Endoproteases that contain proteolytic core domains and ATPase-containing regulatory domains.
Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are usually comprised of large multi-subunit assemblies. The domains can occur within a single peptide chain or on distinct subunits.
a commercially available biotin-ATP analog; structure in first source
RefSeq NP_085571
RefSeq NM_014616
RefSeq NM_029097
RefSeq NM_131684 (atp1a3a); RefSeq NM_131685 (atp1a3b)
RefSeq NM_001142447
RefSeq NM_033276
RefSeq NM_001090874
RefSeq NM_001687
Gene ID: 70495
RefSeq NM_001690
RefSeq NM_015941
RefSeq NM_006095
RefSeq XM_003751492
RefSeq NM_001184
inhibits both MDM2 and MDMX; structure in first source
structure in first source
an APIM-containing cell-penetrating peptide that increases the antineoplastic activity of melphalan for treatment of multiple myeloma; APIM - AlkB homologue 2 PCNA-interacting motif
ATX1 - antoxidant protein1; RefSeq NM_105295; do not confuse with ATX1 protein, Arabidopsis
a member of class of H3K4 methyltransferases; RefSeq NM_117606