iDrugBank

2',5'-Oligoadenylate Synthetase

MESHD015088

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

Synonyms

  • 2',5' Oligoadenylate Synthetase
  • Synthetase, 2',5'-Oligoadenylate
  • (2'-5')An Polymerase
  • 2',5'-Oligo(A) Polymerase
  • 2-5A Synthetase
  • ATP-(2'-5')oligo(A)adenylyltransferase
  • 2',5'-Oligo(A) Synthetase
  • 2,5 Oligoadenylate Polymerase
  • Oligoadenylate Polymerase, 2,5
  • Polymerase, 2,5 Oligoadenylate
  • 2,5 Oligoadenylate Synthetase
  • Oligoadenylate Synthetase, 2,5
  • Synthetase, 2,5 Oligoadenylate
  • 2',5'-Oligoadenylate Polymerase
  • 2',5' Oligoadenylate Polymerase
  • Polymerase, 2',5'-Oligoadenylate

Source last updated 2026-05-24T15:26:14.450Z