iDrugBank

2-Isopropylmalate Synthase

MESHD015079

An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.

Synonyms

  • 2 Isopropylmalate Synthase
  • Synthase, 2-Isopropylmalate
  • alpha-Isopropylmalate Synthase
  • alpha Isopropylmalate Synthase
  • Synthase, alpha-Isopropylmalate

Source last updated 2026-05-24T15:26:14.450Z