Complement C1
MESHD003172
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Synonyms
- C1, Complement
- Complement Component 1
- Component 1, Complement
- C1 Complement
- Complement, C1
- Complement 1
Source last updated 2026-05-24T15:27:57.172Z