Cholera Toxin
MESHD002772
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Synonyms
- Toxin, Cholera
- Cholera Enterotoxin CT
- Enterotoxin CT, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Choleragen
- Choleragenoid
- Cholera Toxin Subunit B
- Cholera Toxin B
- Toxin B, Cholera
- Cholera Toxin B Subunit
- Cholera Toxin Protomer B
- Cholera Toxin Protomer A
- Cholera Toxin Subunit A
- Cholera Toxin A
- Toxin A, Cholera
- Cholera Toxin A Subunit
- Procholeragenoid
Source last updated 2026-05-24T15:28:01.396Z